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- Title
Epigenetic regulation mechanisms of microRNA expression.
- Authors
Morales, Sara; Monzo, Mariano; Navarro, Alfons
- Abstract
MicroRNAs (miRNAs) are single-stranded RNAs of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. They are involved in many physiological and pathological processes, including cell proliferation, apoptosis, development and carcinogenesis. Because of the central role of miRNAs in the regulation of gene expression, their expression needs to be tightly controlled. Here, we summarize the different mechanisms of epigenetic regulation of miRNAs, with a particular focus on DNA methylation and histone modification.
- Subjects
MICRORNA; EPIGENETICS; GENETIC regulation; CELL proliferation; CARCINOGENESIS; DNA methylation
- Publication
Biomolecular Concepts, 2017, Vol 8, Issue 5/6, p203
- ISSN
1868-5021
- Publication type
Article
- DOI
10.1515/bmc-2017-0024