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- Title
Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies.
- Authors
Wanders, Anne J.; Alssema, Marjan; De Hoon, Sabine E.M.; Feskens, Edith J.M.; van Woudenbergh, Geertruida J.; van der Kallen, Carla J.; Zock, Peter L.; Refsum, Helga; Drevon, Christian A.; Elshorbagy, Amany; Schalkwijk, Casper G.; Stehouwer, Coen D.A.; Dekker, Jacqueline M.; van Greevenbroek, Marleen M.J.
- Abstract
<bold><italic>Aims:</italic></bold> To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). <bold><italic>Methods:</italic></bold> Cross-sectional analyses were performed in pooled data from the CODAM (<italic>n</italic> = 469) and Hoorn (<italic>n</italic> = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (µg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. <bold><italic>Results:</italic></bold> Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (<italic>p</italic> values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. <bold><italic>Conclusions:</italic></bold> This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.
- Subjects
BIOMARKERS; ETHANOL; FAT content of food; GAS chromatography; INGESTION; MASS spectrometry; PROBABILITY theory; QUESTIONNAIRES; REGRESSION analysis; SEX distribution; UNSATURATED fatty acids; LINOLEIC acid; DOCOSAHEXAENOIC acid; EICOSAPENTAENOIC acid; BODY mass index; WAIST circumference; ALPHA-linolenic acid
- Publication
Annals of Nutrition & Metabolism, 2018, Vol 72, Issue 2, p117
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000486244