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- Title
Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus.
- Authors
Yun-Sheng Wang; Jun Ye; Xiao Yang; Gui-Ping Zhang; Yong-Hong Cao; Rong Zhang; Wu Dai; Qiu Zhang; Wang, Yun-Sheng; Ye, Jun; Yang, Xiao; Zhang, Gui-Ping; Cao, Yong-Hong; Zhang, Rong; Dai, Wu; Zhang, Qiu
- Abstract
<bold>Introduction: </bold>To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as their correlation with clinical and laboratory indexes, such as blood pressure and lipoprotein.<bold>Material and Methods: </bold>A total of 242 subjects, including 141 NT2DM patients, 48 PDM subjects and 53 healthy controls, were recruited in the present study. Serum RBP-4, Cys C and hs-CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). HCY concentration was determined by the chemical luminescence method.<bold>Results: </bold>There were significant differences in Cys C and hs-CRP among NT2DM patients, PDM subjects and normal controls. In comparison to controls, there were significantly elevated Cys C and hs-CRP levels in PDM (both p < 0.001), and a significantly increased Cys C level in NT2DM (p < 0.001); however, there were no significant differences in Cys C and hs-CRP levels between NT2DM and PDM, and no significant differences of hs-CRP levels between NT2DM and normal controls. No significant differences of RBP-4 and HCY levels among NT2DM, PDM and normal control groups were observed.<bold>Conclusions: </bold>Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease.
- Subjects
TYPE 2 diabetes; C-reactive protein; ENZYME-linked immunosorbent assay; PROTEIN binding; PRODUCT management software
- Publication
Archives of Medical Science, 2019, Vol 15, Issue 5, p1203
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms.2018.79565