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- Title
Metformin Attenuates Cognitive Impairments in Hypoxia-Ischemia Neonatal Rats via Improving Remyelination.
- Authors
Qi, Boxiang; Hu, Libao; Zhu, Lei; Shang, Lei; Sheng, Liping; Wang, Xuecheng; Liu, Na; Wen, Nana; Yu, Xiaohe; Wang, Qihong; Yang, Yujia
- Abstract
Perinatal hypoxia-ischemia (H/I) causes brain injury and myelination damage. Finding efficient methods to restore myelination is critical for the recovery of brain impairments. By applying an H/I rat model, we demonstrate that metformin (Met) treatment significantly ameliorates the loss of locomotor activity and cognition of H/I rat in the Morris water maze and open field task tests. After administration of Met to H/I rat, the proliferation of Olig2+ oligodendrocyte progenitor cells and the expression of myelin basic protein are obviously increased in the corpus callosum. Additionally, the myelin sheaths are more compact and the impairments are evidently attenuated. These data indicate that Met is beneficial for the amelioration of H/I-induced myelination and behavior deficits.
- Subjects
BRAIN injuries; MYELINATION; METFORMIN; PROGENITOR cells; CORPUS callosum
- Publication
Cellular & Molecular Neurobiology, 2017, Vol 37, Issue 7, p1269
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-016-0459-8