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- Title
Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010.
- Authors
Buchacz, Kate; Lau, Bryan; Yuezhou Jing; Bosch, Ronald; Abraham, Alison G.; Gill, M. John; Silverberg, Michael J.; Goedert, James J.; Sterling, Timothy R.; Althoff, Keri N.; Martin, Jeffrey N.; Burkholder, Greer; Gandhi, Neel; Hasina Samji; Patel, Pragna; Rachlis, Anita; Thorne, Jennifer E.; Napravnik, Sonia; Henry, Keith; Mayor, Angel
- Abstract
<bold>Background: </bold>There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada.<bold>Methods: </bold>We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010.<bold>Results: </bold>A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection.<bold>Conclusions: </bold>For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.
- Subjects
OPPORTUNISTIC infections; HIV; AIDS; ANTIRETROVIRAL agents; PNEUMOCYSTIS jiroveci; PNEUMONIA
- Publication
Journal of Infectious Diseases, 2016, Vol 214, Issue 6, p862
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw085