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- Title
HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
- Authors
Matthews, Philippa C.; Carlson, Jonathan M.; Beloukas, Apostolos; Malik, Amna; Jooste, Pieter; Ogwu, Anthony; Shapiro, Roger; Riddell, Lynn; Chen, Fabian; Luzzi, Graz; Jesuthasan, Gerald; Jeffery, Katie; Jojic, Nebojsa; Ndung'u, Thumbi; Carrington, Mary; Goulder, Philip J. R.; Maria Geretti, Anna; Klenerman, Paul; Geretti, Anna Maria
- Abstract
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.
- Subjects
HEPATITIS B virus; HIV; HIV-positive persons; MEDICAL virology; ANTIGENS; HIV infection complications; HIV infection epidemiology; HEPATITIS B; HIV infections; LONGITUDINAL method; RESEARCH funding; VIRAL antigens; HLA-B27 antigen; DISEASE prevalence; RECEIVER operating characteristic curves; MIXED infections; DISEASE complications
- Publication
Journal of Infectious Diseases, 2016, Vol 213, Issue 8, p1248
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv592