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- Title
Sex Differences in Pediatric Infectious Diseases.
- Authors
Muenchhoff, Maximilian; Goulder, Philip J. R.
- Abstract
The success of the immune response is finely balanced between, on the one hand, the need to engage vigorously with, and clear, certain pathogens; and, on the other, the requirement to minimize immunopathology and autoimmunity. Distinct immune strategies to achieve this balance have evolved in females and males and also in infancy through to adulthood. Sex differences in outcome from a range of infectious diseases can be identified from as early as fetal life, such as in congenital cytomegalovirus infection. The impact of sex hormones on the T-helper 1/T-helper 2 cytokine balance has been proposed to explain the higher severity of most infectious diseases in males. In the minority where greater morbidity and mortality is observed in females, this is hypothesized to arise because of greater immunopathology and/or autoimmunity. However, a number of unexplained exceptions to this rule are described. Studies that have actually measured the sex differences in children in the immune responses to infectious diseases and that would further test these hypotheses, are relatively scarce.
- Subjects
SEX differences (Biology); COMMUNICABLE diseases in children; IMMUNE response; IMMUNOPATHOLOGY; AUTOIMMUNITY; HEALTH outcome assessment
- Publication
Journal of Infectious Diseases, 2014, Vol 209, Issue suppl_3, pS120
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiu232