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- Title
Hepatitis B Virus Coinfection Negatively Impacts HIV Outcomes in HIV Seroconverters.
- Authors
Chun, Helen M.; Roediger, Mollie P.; Hullsiek, Katherine Huppler; Thio, Chloe L.; Agan, Brian K.; Bradley, William P.; Peel, Sheila A.; Jagodzinski, Linda L.; Weintrob, Amy C.; Ganesan, Anuradha; Wortmann, Glenn; Crum-Cianflone, Nancy F.; Maguire, Jason D.; Landrum, Michael L.
- Abstract
Background. Understanding the impact of hepatitis B virus (HBV) in human immunodeficiency virus (HIV) coinfection has been limited by heterogeneity of HIV disease. We evaluated HBV coinfection and HIV-related disease progression in a cohort of HIV seroconverters. Methods. Participants with HIV diagnosis seroconversion window of ≤3 years and serologically confirmed HBV infection (HB) status were classified at baseline into 4 HB groups. The risk of clinical AIDS/death in HIV seroconverters was calculated by HB status. Results. Of 2352 HIV seroconverters, 474 (20%) had resolvedHB, 82 (3%) had isolated total antibody to hepatitis B core antigen (HBcAb), and 64 (3%) had chronic HB. Unadjusted rates (95% confidence intervals [CIs]) of clinical AIDS/ death for theHB-negative, resolvedHB, isolated HBcAb, and chronic HB groups were 2.43 (2.15-2.71); 3.27 (2.71-3.84); 3.75 (2.25-5.25); and 5.41 (3.41-7.42), respectively. Themultivariable risk of clinical AIDS/death was significantly higher in the chronic HB group compared to the HB-negative group (hazard ratio [HR], 1.80; 95% CI, 1.20-2.69); while the HRs were increased but nonsignificant for those with resolved HB (HR, 1.17; 95% CI, .94-1.46) and isolated HBcAb (HR, 1.14; 95% CI, .75-1.75). Conclusions. HBV coinfection has a significant impact on HIV outcomes. The hazard for an AIDS or death event is almost double for those with chronic HB compared, with HIV-monoinfected persons.
- Subjects
SEROCONVERSION; HEPATITIS B virus; HEALTH outcome assessment; HIV infections; HETEROGENEITY; DISEASE progression; COHORT analysis
- Publication
Journal of Infectious Diseases, 2012, Vol 205, Issue 2, p185
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jir720