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Generation of Stereochemically Defined Tetrasubstituted Enolborinates by 1,4-Hydroboration of α,β-Unsaturated Morpholine Carboxamides with (Diisopinocampheyl)borane.
Published in:
Angewandte Chemie International Edition, 2013, v. 52, n. 49, p. 12888, doi. 10.1002/anie.201307302
By:
- Allais, Christophe;
- Tsai, Andy S.;
- Nuhant, Philippe;
- Roush, William R.
Publication type:
Article
Diisopinocampheylborane-Mediated Reductive Aldol Reactions: Highly Enantio- and Diastereoselective Synthesis of syn Aldols from N-Acryloylmorpholine.
Published in:
Angewandte Chemie International Edition, 2013, v. 52, n. 33, p. 8703, doi. 10.1002/anie.201302535
By:
- Nuhant, Philippe;
- Allais, Christophe;
- Roush, William R.
Publication type:
Article
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003588
By:
- McCall, Laura-Isobel;
- El Aroussi, Amale;
- Choi, Jun Yong;
- Vieira, Debora F.;
- De Muylder, Geraldine;
- Johnston, Jonathan B.;
- Chen, Steven;
- Kellar, Danielle;
- Siqueira-Neto, Jair L.;
- Roush, William R.;
- Podust, Larissa M.;
- McKerrow, James H.
Publication type:
Article
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003588
By:
- McCall, Laura-Isobel;
- El Aroussi, Amale;
- Choi, Jun Yong;
- Vieira, Debora F.;
- De Muylder, Geraldine;
- Johnston, Jonathan B.;
- Chen, Steven;
- Kellar, Danielle;
- Siqueira-Neto, Jair L.;
- Roush, William R.;
- Podust, Larissa M.;
- McKerrow, James H.
Publication type:
Article
Generation of Stereochemically Defined Tetrasubstituted Enolborinates by 1,4-Hydroboration of α,β-Unsaturated Morpholine Carboxamides with (Diisopinocampheyl)borane.
Published in:
Angewandte Chemie, 2013, v. 125, n. 49, p. 13126, doi. 10.1002/ange.201307302
By:
- Allais, Christophe;
- Tsai, Andy S.;
- Nuhant, Philippe;
- Roush, William R.
Publication type:
Article
Diisopinocampheylborane-Mediated Reductive Aldol Reactions: Highly Enantio- and Diastereoselective Synthesis of syn Aldols from N-Acryloylmorpholine.
Published in:
Angewandte Chemie, 2013, v. 125, n. 33, p. 8865, doi. 10.1002/ange.201302535
By:
- Nuhant, Philippe;
- Allais, Christophe;
- Roush, William R.
Publication type:
Article
Enantio‐ and Diastereoselective (Ipc)<sub>2</sub>BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides.
Published in:
Helvetica Chimica Acta, 2023, v. 106, n. 12, p. 1, doi. 10.1002/hlca.202300126
By:
- Pedzisa, Lee;
- Monastyrskyi, Andrii;
- Parker, Camille D.;
- Roush, William R.
Publication type:
Article
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Published in:
PLoS Neglected Tropical Diseases, 2017, v. 11, n. 12, p. 1, doi. 10.1371/journal.pntd.0006132
By:
- Calvet, Claudia Magalhaes;
- Choi, Jun Yong;
- Thomas, Diane;
- Suzuki, Brian;
- Hirata, Ken;
- Lostracco-Johnson, Sharon;
- de Mesquita, Liliane Batista;
- Nogueira, Alanderson;
- Meuser-Batista, Marcelo;
- Silva, Tatiana Araujo;
- Siqueira-Neto, Jair Lage;
- Roush, William R.;
- de Souza Pereira, Mirian Claudia;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
Total Synthesis of (−)-Bafilomycin A.
Published in:
Angewandte Chemie International Edition, 1999, v. 38, n. 11, p. 1652, doi. 10.1002/(SICI)1521-3773(19990601)38:11<1652::AID-ANIE1652>3.0.CO;2-K
By:
- Scheidt, Karl A.;
- Tasaka, Akihiro;
- Bannister, Thomas D.;
- Wendt, Michael D.;
- Roush, William R.
Publication type:
Article
Synthesis of highly functionalized naphthoate precursors to damavaricin D — Observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized β-naphthol derivatives.
Published in:
Canadian Journal of Chemistry, 2001, v. 79, n. 11, p. 1711, doi. 10.1139/cjc-79-11-1711
By:
- Roush, William R;
- Madar, David J;
- Coffey, D Scott
Publication type:
Article
Expanding the Binding Envelope of CYP51 Inhibitors Targeting Trypanosoma cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives.
Published in:
ChemBioChem, 2014, v. 15, n. 8, p. 1111, doi. 10.1002/cbic.201402027
By:
- Vieira, Debora F.;
- Choi, Jun Yong;
- Roush, William R.;
- Podust, Larissa M.
Publication type:
Article
Suppression of T<sub>H</sub>17 differentiation and autoimmunity by a synthetic ROR ligand.
Published in:
Nature, 2011, v. 472, n. 7344, p. 491, doi. 10.1038/nature10075
By:
- Solt, Laura A.;
- Kumar, Naresh;
- Nuhant, Philippe;
- Yongjun Wang;
- Lauer, Janelle L.;
- Jin Liu;
- Istrate, Monica A.;
- Kamenecka, Theodore M.;
- Roush, William R.;
- Vidović, Dušica;
- Schürer, Stephan C.;
- Jihong Xu;
- Wagoner, Gail;
- Drew, Paul D.;
- Griffin, Patrick R.;
- Burris, Thomas P.
Publication type:
Article
Therapeutic targeting of casein kinase 1δ in breast cancer.
Published in:
Science Translational Medicine, 2015, v. 7, n. 318, p. 1, doi. 10.1126/scitranslmed.aac8773
By:
- Rosenberg, Laura H.;
- Lafitte, Marie;
- Quereda, Victor;
- Grant, Wayne;
- Weimin Chen;
- Bibian, Mathieu;
- Noguchi, Yoshihiko;
- Fallahi, Mohammad;
- Chunying Yang;
- Chang, Jenny C.;
- Roush, William R.;
- Cleveland, John L.;
- Duckett, Derek R.
Publication type:
Article
Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation.
Published in:
Antibody Therapeutics, 2019, v. 2, n. 4, p. 71, doi. 10.1093/abt/tbz009
By:
- Nilchan, Napon;
- Li, Xiuling;
- Pedzisa, Lee;
- Nanna, Alex R;
- Roush, William R;
- Rader, Christoph
Publication type:
Article
Systems analysis of intracellular pH vulnerabilities for cancer therapy.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05261-x
By:
- Persi, Erez;
- Duran-Frigola, Miquel;
- Damaghi, Mehdi;
- Roush, William R.;
- Aloy, Patrick;
- Cleveland, John L.;
- Gillies, Robert J.;
- Ruppin, Eytan
Publication type:
Article
Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01257-1
By:
- Nanna, Alex R.;
- Xiuling Li;
- Walseng, Even;
- Pedzisa, Lee;
- Goydel, Rebecca S.;
- Hymel, David;
- Burke Jr., Terrence R.;
- Roush, William R.;
- Rader, Christoph
Publication type:
Article
In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 9, p. 1, doi. 10.1371/journal.pntd.0000825
By:
- Chen, Yen Ting;
- Brinen, Linda S.;
- Kerr, Iain D.;
- Hansell, Elizabeth;
- Doyle, Patricia S.;
- McKerrow, James H.;
- Roush, William R.
Publication type:
Article
In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 9, p. 1, doi. 10.1371/journal.pntd.0000825
By:
- Yen Ting Chen;
- Brinen, Linda S.;
- Kerr, Iain D.;
- Hansell, Elizabeth;
- Doyle, Patricia S.;
- McKerrow, James H.;
- Roush, William R.
Publication type:
Article
Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.
Published in:
Journal of Molecular Medicine, 2019, v. 97, n. 4, p. 523, doi. 10.1007/s00109-019-01753-5
By:
- Wang, Luping;
- Schmidt, Sarah;
- Larsen, Petra P.;
- Meyer, Johanna H.;
- Roush, William R.;
- Latz, Eicke;
- Holz, Frank G.;
- Krohne, Tim U.
Publication type:
Article
Broadening the Existing Intergenerational Structure of Scholarly Development in Chemistry.
Published in:
Peer Review, 2004, v. 6, n. 3, p. 19
By:
- Coppola, Brian P.;
- Roush, William R.
Publication type:
Article

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