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- Title
The long pentraxin PTX3: a novel serum marker to improve the prediction of osteoporosis and osteoarthritis bone-related phenotypes.
- Authors
Visconti, Virginia Veronica; Greggi, Chiara; Fittipaldi, Simona; Casamassima, Donato; Tallarico, Maria Grazia; Romano, Francesco; Botta, Annalisa; Tarantino, Umberto
- Abstract
Background: The long pentraxin PTX3 is generating great interest given the recent discovery of its involvement in bone metabolism. This study investigates the role of circulating PTX3 as a marker of bone-related phenotypes in patients with osteoporosis (OP) and osteoarthritis (OA). Methods: Serum PTX3 levels were determined using an enzyme-linked immunosorbent assay (ELISA) in a total of OP (n=32), OA (n=19) patients and healthy controls (CTR; n=25). ROC curve analysis was carried out to evaluate the potential of PTX3 for the diagnosis of bone-related phenotypes. In addition, the association between PTX3 serum levels and biochemical markers was estimated by Spearman correlation analysis. Results: Serum analysis reveals a statistically significant increase of PTX3 levels in OP and OA patients, compared to CTR subjects (**** p < 0.0001, **** p < 0.0001). ROC curve of PTX3 levels exhibits an excellent sensitivity and specificity for OP and OA diseases (**** p < 0.0001 and **** p < 0.0001, respectively). Moreover, serum PTX3 levels are positively associated with ALP (r = − 0.5257, p = 0.0083) and PTH levels (r = 0.4704, p = 0.0203) in OP patients. Conclusions: These results confirm the pivotal role of PTX3 in bone metabolism and suggest its potential use as a predictor of OP and OA bone-related phenotypes.
- Subjects
OSTEOPOROSIS diagnosis; BONE metabolism; BIOMARKERS; C-reactive protein; STATISTICS; ALKALINE phosphatase; PREDICTIVE tests; INFLAMMATION; PARATHYROID hormone; OSTEOARTHRITIS; ENZYME-linked immunosorbent assay; RECEIVER operating characteristic curves; DATA analysis; PHENOTYPES
- Publication
Journal of Orthopaedic Surgery & Research, 2021, Vol 16, Issue 1, p1
- ISSN
1749-799X
- Publication type
Article
- DOI
10.1186/s13018-021-02440-3