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- Title
TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.
- Authors
Wu, Y.; Zhou, B. P.
- Abstract
Tumour necrosis factor-alpha (TNF-alpha) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-alpha in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-alpha as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-alpha and the nuclear factor-kappaB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
- Subjects
TUMOR necrosis factors; CANCER; CYTOKINES; HOMEOSTASIS; METASTASIS; CANCER invasiveness; NEOVASCULARIZATION; BIOLOGICAL models; RESEARCH; ANIMAL experimentation; RESEARCH methodology; NEOPLASTIC cell transformation; EVALUATION research; MEDICAL cooperation; CELL motility; COMPARATIVE studies; DNA-binding proteins; RESEARCH funding; TUMORS; TRANSCRIPTION factors
- Publication
British Journal of Cancer, 2010, Vol 102, Issue 4, p639
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605530