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- Title
Increase in HCV Incidence among Men Who Have Sex with Men in Amsterdam Most Likely Caused by Sexual Transmission.
- Authors
van de Laar, Thijs J. W.; van der Bij, Akke K.; Prins, Maria; Bruisten, Sylvia M.; Brinkman, Kees; Ruys, Thomas A.; van der Meer, Jan T. M.; de Vries, Henry J. C.; Mulder, Jan-Willem; van Agtmael, Michiel; Jurriaans, Suzanne; Wolthers, Katja C.; Coutinho, Roel A.
- Abstract
We retrospectively screened 1836 men who have sex with men (MSM) participating in the Amsterdam Cohort Studies (1984-2003) for hepatitis C virus (HCV) antibodies. HCV incidence was 0.18/100 person-years (PY) in human immunodeficiency virus (HIV)-positive MSM (8/4408 PY [95% confidence interval {CI}, 0.08-0.36]) but was 0/100 PY in MSM without HIV (0/7807 PY [95% CI, 0.00-0.05]). After 2000, HCV incidence among HIV-positive men increased 10-fold to 0.87/100 PY (5/572 PY [95% CI, 0.28-2.03]). Additional hospital cases (n = 34) showed that MSM in Amsterdam who acquired HCV infection after 2000 reported high rates of ulcerative sexually transmitted infections (59%) and rough sexual techniques (56%), denied injection drug use, and were infected mainly with the difficult-to-treat HCV genotypes 1 (56%) and 4 (36%). Phylogenetic analysis showed 3 monophyletic clusters of MSM-specific HCV strains. The emergence of an MSM-specific transmission network suggests that HIV-positive MSM with high-risk sexual behaviors are at risk for sexually acquired HCV. Targeted prevention and routine HCV screening among HIV-positive MSM is needed to deter the spread of HCV.
- Subjects
AMSTERDAM (Netherlands); NETHERLANDS; HEPATITIS C virus; HIV; SEXUAL intercourse; COHORT analysis
- Publication
Journal of Infectious Diseases, 2007, Vol 196, Issue 2, p230
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/518796