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- Title
Staphylococcus aureus carriers neutralize superantigens by antibodies specific for their colonizing strain: a potential explanation for their improved prognosis in severe sepsis.
- Authors
Holtfreter S; Roschack K; Eichler P; Eske K; Holtfreter B; Kohler C; Engelmann S; Hecker M; Greinacher A; Bröker BM
- Abstract
Staphylococcus aureus is one of the most common causes of hospital-acquired infections. At the same time, 25% of healthy persons are symptom-free S. aureus carriers, and they have an increased risk of developing nosocomial S. aureus septicemia. Paradoxically, their prognosis is much better than that of noncarriers. We compared the antibody profiles for carriers and noncarriers toward S. aureus superantigens. In carriers, we found high titers of neutralizing antibodies specific for those superantigens that are expressed by their colonizing strain. The results show that carriage status confers strain-specific humoral immunity, which may contribute to protection during S. aureus septicemia. Copyright © 2006 Infectious Diseases Society of America
- Publication
Journal of Infectious Diseases, 2006, Vol 193, Issue 9, p1275
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/503048