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- Title
Majority of Interferon-ϒ--Producing CD4 + Cells in Patients Infected with Human T Cell Lymphotrophic Virus Do Not Express Tax Protein.
- Authors
Mitre, Edward; Thompson, Robert W.; Carvalho, Edgar M.; Nutman, Thomas B.; Neva, Franklin A.
- Abstract
The present study was conducted to determine whether interferon (IFN)-γ production by CD4[sup +] cells in patients infected with human T cell lymphotropic virus (HTLV) is associated with expression of Tax, an HTLV type 1 (HTLV-1) transactivator. The frequency of IFN-γ production from CD4[sup +] cells was greater in HTLV-1-infected patients (n = 21) than in uninfected (n = 3) and Strongyloides stercoralis-infected patients (n = 4), and greater in patients with HTLV-1 with detectable Tax than in patients with HTLV-1 with undetectable Tax. In the patients with HTLV-1 with detectable Tax, the majority of CD4[sup +] cells making IFN-γ did not express Tax.
- Subjects
INTERFERONS; CD antigens; T cells
- Publication
Journal of Infectious Diseases, 2003, Vol 188, Issue 3, p428
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/376529