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- Title
Interobserver Agreement for the Detection of Barrett's Esophagus with Optical Frequency Domain Imaging.
- Authors
Sauk, Jenny; Coron, Emmanuel; Kava, Lauren; Suter, Melissa; Gora, Michalina; Gallagher, Kevin; Rosenberg, Mireille; Ananthakrishnan, Ashwin; Nishioka, Norman; Lauwers, Gregory; Woods, Kevin; Brugge, William; Forcione, David; Bouma, Brett; Tearney, Guillermo
- Abstract
Background: Optical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm. Aim: Using validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett's esophagus (BE), the objective of this study was to determine the inter- and intra-observer agreements by a large number of OFDI readers for differentiating these tissues. Methods: OFDI images were obtained from nine subjects undergoing screening and surveillance for BE. Sixty-four OFDI image regions of interest were randomly selected for review. A training set of 19 images was compiled distinguishing squamous mucosa from gastric cardia and BE using previously validated OCT criteria. The ten readers then interpreted images in a test set of 45 different images of squamous mucosa ( n = 15), gastric cardia ( n = 15), or BE ( n = 15). Interobserver agreement differentiating the three tissue types and BE versus non-BE mucosa was determined using multi-rater Fleiss's κ value. The images were later randomized again and four readers repeated the test 3 weeks later to assess intraobserver reliability. Results: All ten readers showed excellent agreement for the differentiation of BE versus non-BE mucosa (κ = 0.811 p < 0.0001) and for differentiating BE versus gastric cardia versus squamous mucosa (κ = 0.866, p < 0.0001). For the four readers who repeated the test, the median intraobserver agreement (BE vs. non-BE) was high (κ = 0.975, IQR: 0.94, 1.0). Conclusions: Trained readers have a high interobserver agreement for differentiating BE, squamous, and gastric cardia mucosa using OFDI.
- Subjects
BARRETT'S esophagus; DIAGNOSTIC imaging; GASTRIC mucosa; CROSS-sectional imaging; OPTICAL coherence tomography; ENDOSCOPY; DIAGNOSIS
- Publication
Digestive Diseases & Sciences, 2013, Vol 58, Issue 8, p2261
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-013-2625-x