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- Title
Predictive factors for response to peginterferon-alpha and ribavirin treatment of chronic HCV infection in patients aged 65 years and more.
- Authors
Giannini, Edoardo; Basso, Monica; Savarino, Vincenzo; Picciotto, Antonino; Giannini, Edoardo G
- Abstract
<bold>Background: </bold>Elderly patients with chronic hepatitis C virus (HCV) infection represent an understudied population, and little is known regarding the predictive factors for sustained virological response (SVR) to antiviral therapy in these patients.<bold>Aims: </bold>To evaluate the efficacy of pegylated interferon (PEG-IFN) and ribavirin therapy in chronic HCV patients aged 65 years, and identify pre- and on-treatment predictors of SVR.<bold>Methods: </bold>We studied 57 patients aged ≥65 years who underwent PEG-IFN and ribavirin treatment, evaluating the SVR rate and its association with pre-treatment demographic, clinical, biochemical, and virological parameters. Furthermore, we assessed whether 12-week serum HCV-RNA assessment might predict SVR.<bold>Results: </bold>A SVR was obtained in 25 patients (45%). The only pre-treatment predictor of SVR was HCV genotype 2 and 3 (P = 0.02). A positive serum HCV-RNA or a decline in viral load ≤2log(10) at week 12 had 100% negative predictive value for SVR. No major liver-related events or deaths occurred during therapy. Treatment was discontinued due to side effects-mainly cardiovascular-in 10 patients (17%).<bold>Conclusion: </bold>Pre- and on-treatment virological parameters can be used to identify elderly patients who are more likely to obtain a SVR to standard-of-care antiviral therapy for chronic HCV infection.
- Subjects
HEPATITIS C treatment; INTERFERONS; VIROLOGY; ANTIVIRAL agents; HEPATITIS C virus; FLAVIVIRAL diseases; DRUG side effects; RIBAVIRIN
- Publication
Digestive Diseases & Sciences, 2010, Vol 55, Issue 11, p3193
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-010-1408-x