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- Title
Seizure Control with Add-On Eslicarbazepine in Two Patients with Dravet Syndrome.
- Authors
Oliveira, Vanessa; Chaves, João
- Abstract
Although all sodium channel blockers are avoided in patients with Dravet syndrome, the slight differences in their mechanism of action may explain our patients favourable outcome. Both of our adult Dravet patients presented a refractory epilepsy, having frequent GTC seizures among other generalised seizures. Keywords: Dravet; Eslicarbazepine; Myoclonic; Epilepsy EN Dravet Eslicarbazepine Myoclonic Epilepsy 732 733 2 08/28/21 20210901 NES 210901 Dravet syndrome is an epileptic encephalopathy with a genetic aetiology, in 70%-80% due to mutations in the neuronal voltage-gated sodium channel (VGSC) -subunit ( I SCN1A i ) gene.1,2 It usually presents in the first year of life, with generalised tonic-clonic (GTC) or hemiconvulsive seizures, often triggered by hyperthermia3.
- Subjects
EPILEPSY; SEIZURES (Medicine); SYNDROMES; SODIUM channel blockers
- Publication
Canadian Journal of Neurological Sciences, 2021, Vol 48, Issue 5, p732
- ISSN
0317-1671
- Publication type
Letter
- DOI
10.1017/cjn.2020.274