We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The relation of mTOR with diabetic complications and insulin resistance in patients with type 2 diabetes mellitus.
- Authors
Amin, Noha G.; Rahim, A. Abdel; Rohoma, Kamel; Elwafa, Reham A.Abo; Dabees, Hossam M. F.; Elrahmany, Shimaa
- Abstract
Background: Dysregulation of the mechanistic target of rapamycin (mTOR) has been related to several metabolic conditions, notably obesity and type 2 diabetes (T2DM). This study aimed to evaluate the role of mTOR in patients with T2DM, and its relationship with insulin resistance and microvascular complications. Methods: This case-control study was conducted on 90 subjects attending the Outpatient Internal Medicine Clinic in Damanhur Teaching Hospital. Subjects were divided into 3 groups, Group I: 20 healthy controls, Group II: 20 subjects with T2DM without complications, and Group III: 50 subjects with T2DM with microvascular complications. An Enzyme-linked immunosorbent assay was used to measure serum mTOR levels. T2DM and diabetic complications were defined according to the diagnostic criteria of the American Diabetes Association. Results: The results revealed significant positive correlations to HbA1c (r = 0.530, P < 0.001), fasting glucose (r = 0.508, P < 0.001), and HOMA- IR (r = 0.559, P < 0.001), and a significant negative correlation to eGFR (r=-0.370, P = 0.002). Multivariate analysis revealed an independent association of mTOR and HbA1c values with the presence of microvascular complications. The prediction of microvascular complications was present at a cutoff value of 8 ng/ml mTOR with a sensitivity of 100% and specificity of 95% with an AUC of 0.983 and a p-value < 0.001. Conclusion: mTOR is a prognostic marker of diabetic microvascular and is associated with insulin resistance in patients with T2DM. Trial Registration: The study was conducted following the Declaration of Helsinki, and approved by the Ethics Committee of Alexandria University (0201127, 19/7/2018).
- Subjects
TYPE 2 diabetes; INSULIN resistance; ENZYME-linked immunosorbent assay; PROGNOSIS; REFERENCE values
- Publication
Diabetology & Metabolic Syndrome, 2024, Vol 16, Issue 1, p1
- ISSN
1758-5996
- Publication type
Article
- DOI
10.1186/s13098-024-01450-5