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- Title
Association Between Nickel Exposure and Metabolic Syndrome: Data from NHANES 2017–2018.
- Authors
Luo, Xiao-Min; Tang, Min; Wei, Xiao-Hui; Tang, Xiaofang; Peng, Yong-De
- Abstract
Previous studies have found a possible association between nickel and metabolic syndrome (MetS), but with conflicting results. No studies have determined whether nickel exposure increases the prevalence of MetS in the general U.S. population. Therefore, we used data from the National Health and Nutrition Examination Survey (NHANES) to assess the association between urinary nickel and MetS. Since urinary nickel levels were presented as a skewed distribution, they were normalized using a logarithmic transformation. Weighted multivariate logistic models, restricted cubic spline, threshold effect analysis, and subgroup analyses were used to examine the association between urinary nickel concentration and the risk of MetS and its components. Based on data from 1577 participants, individuals in the second, third, and fourth quartiles of urinary nickel had an adjusted OR for MetS of 1.42 (95% CI: 0.88, 2.28), 2.00 (95% CI: 1.22, 3.28), and 1.68 (95% CI: 1.05, 2.70), respectively, representing an inverted "L"-shaped nonlinear dose–response relationship with an inflection point at 0.2141 ng/L. Patients over the age of 40, males, less educated, and smokers are more susceptible to nickel exposure. In addition, there were significant associations between nickel and most components of the MetS, with the strongest to weakest correlations being high fasting glucose, reduced high-density lipoprotein, abdominal obesity, and elevated blood pressure; however, there was no significant correlation between nickel and hyperlipidemia. In conclusion, environmental nickel exposure increases the prevalence of MetS in U.S. adults, particularly in males over 40 years of age, those with less education, and smokers.
- Subjects
HEALTH &; Nutrition Examination Survey; SKEWNESS (Probability theory); HIGH density lipoproteins; METABOLIC syndrome; ENVIRONMENTAL exposure
- Publication
Cardiovascular Toxicology, 2024, Vol 24, Issue 10, p1028
- ISSN
1530-7905
- Publication type
Article
- DOI
10.1007/s12012-024-09912-y