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- Title
High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer.
- Authors
Wagensveld, Lilian van; Nyen, Tom Van; Annibali, Daniela; Sonke, Gabe S; Kruitwagen, Roy F P M; Amant, Frederic; Horlings, Hugo M
- Abstract
Introduction High-grade serous ovarian cancer (HGSOC) is characterized by high mortality and prevalent recurrences. This study investigates the prognostic value of phosphoglycerate dehydrogenase (PHGDH) in HGSOC which has been linked to metabolic reprogramming and recurrences in other cancers. Methods Data from 306 patients with advanced-stage HGSOC treated between 2008 and 2015 were analyzed. PHGDH expression levels were determined using immunohistochemistry and categorized as "low" or "high." Results PHGDH-high was associated with higher FIGO stage and increased use of neoadjuvant chemotherapy. Patients with PHGDH-high tumors had significantly worse survival than PHDH-low, even after adjusting for confounding factors.
- Subjects
RESEARCH funding; OVARIAN tumors; TUMOR markers; TUMOR grading; IMMUNOHISTOCHEMISTRY; GENE expression; OXIDOREDUCTASES; MEDICAL records; ACQUISITION of data; COMBINED modality therapy; TUMOR classification; SURVIVAL analysis (Biometry)
- Publication
Oncologist, 2024, Vol 29, Issue 9, pe1231
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1093/oncolo/oyae161