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- Title
Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst.
- Authors
Gao, Xiaolong; Wei, Huan; Ma, Wenjie; Wu, Wenjie; Ji, Wenliang; Mao, Junjie; Yu, Ping; Mao, Lanqun
- Abstract
Electrochemical methods with tissue-implantable microelectrodes provide an excellent platform for real-time monitoring the neurochemical dynamics in vivo due to their superior spatiotemporal resolution and high selectivity and sensitivity. Nevertheless, electrode implantation inevitably damages the brain tissue, upregulates reactive oxygen species level, and triggers neuroinflammatory response, resulting in unreliable quantification of neurochemical events. Herein, we report a multifunctional sensing platform for inflammation-free in vivo analysis with atomic-level engineered Fe single-atom catalyst that functions as both single-atom nanozyme with antioxidative activity and electrode material for dopamine oxidation. Through high-temperature pyrolysis and catalytic performance screening, we fabricate a series of Fe single-atom nanozymes with different coordination configurations and find that the Fe single-atom nanozyme with FeN4 exhibits the highest activity toward mimicking catalase and superoxide dismutase as well as eliminating hydroxyl radical, while also featuring high electrode reactivity toward dopamine oxidation. These dual functions endow the single-atom nanozyme-based sensor with anti-inflammatory capabilities, enabling accurate dopamine sensing in living male rat brain. This study provides an avenue for designing inflammation-free electrochemical sensing platforms with atomic-precision engineered single-atom catalysts. Electrochemical methods are promising for monitoring neurochemical dynamics, but are limited by inflammation effects from electrode implantation. Here, the authors report the development of a single-atom catalyst that acts both as an antioxidative nanozyme and an electrode material for the inflammation-free sensing of dopamine in the brain.
- Subjects
REACTIVE oxygen species; HYDROXYL group; SUPEROXIDE dismutase; MICROELECTRODES; BRAIN damage; CATALASE
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-52279-5