We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa.
- Authors
Nyathi, Sindiso; Rezende, Izabela M.; Walter, Katharine S.; Thongsripong, Panpim; Mutuku, Francis; Ndenga, Bryson; Mbakaya, Joel O.; Aswani, Peter; Musunzaji, Peter S.; Chebii, Philip K.; Maina, Priscilla W.; Mutuku, Paul S.; Ng'ang'a, Charles M.; Malumbo, Said L.; Jembe, Zainab; Vu, David M.; Mordecai, Erin A.; Bennett, Shannon; Andrews, Jason R.; LaBeaud, A. Desiree
- Abstract
Despite the increasing burden of dengue, the regional emergence of the virus in Kenya has not been examined. This study investigates the genetic structure and regional spread of dengue virus-2 in Kenya. Viral RNA from acutely ill patients in Kenya was enriched and sequenced. Six new dengue-2 genomes were combined with 349 publicly available genomes and phylogenies used to infer gene flow between Kenya and other countries. Analyses indicate two dengue-2 Cosmopolitan genotype lineages circulating in Kenya, linked to recent outbreaks in coastal Kenya and Burkina Faso. Lineages circulating in Western, Southern, and Eastern Africa exhibiting similar evolutionary features are also reported. Phylogeography suggests importation of dengue-2 into Kenya from East and Southeast Asia and bidirectional geneflow. Additional lineages circulating in Africa are also imported from East and Southeast Asia. These findings underscore how intermittent importations from East and Southeast Asia drive dengue-2 circulation in Kenya and Africa more broadly. There is limited data about local emergence and spread of dengue virus in East African countries. In this study, the authors investigate genetic and geographic epidemiology of dengue virus 2 in East Africa and report co-circulation of multiple distinct lineages introduced from regions in East and Southeast Asia.
- Subjects
GENETIC epidemiology; GENE flow; MOLECULAR epidemiology; VIRAL transmission; GENOMES
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-51018-0