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- Title
Artificial intelligence for predicting response to neoadjuvant chemotherapy for bladder cancer: A comprehensive systematic review and meta-analysis.
- Authors
Vinícius Suartz, Caio; Motta Martinez, Lucas; Dener Cordeiro, Maurício; Ausley Flores, Hunter; Kodama, Sarah; Cardili, Leonardo; Maurício Mota, José; Almeida Coelho, Fernando Morbeck; de Bessa Junior, José; Pires Camargo, Cristina; Yuen-Chun Teoh, Jeremy; Shariat, Shahrokh F.; Toren, Paul; Carlos Nahas, William; Alves Ribeiro-Filho, Leopoldo
- Abstract
INTRODUCTION: Neoadjuvant cisplatin-based combination chemotherapy (NAC) followed by radical cystectomy is the standard of care for cisplatin-fit patients harboring muscleinvasive bladder cancer (MIBC). Prediction of response to NAC is essential for clinical decision-making regarding alternatives in case of non-response, and bladder-sparing in case of complete response. This research aimed to assess the performance of machine learning in predicting therapeutic response following NAC treatment in patients with MIBC. METHODS: A systematic review adhering to the PRISMA guidelines was conducted until July 2023. The study integrated articles relating to artificial intelligence and NAC response in MIBC from various databases. The quality of articles was evaluated using the Quality Assessment Tool for Diagnostic Accuracy Studies 2 (QUADAS-2). A meta-analysis was subsequently performed on selected studies to determine the sensitivity and specificity of machine learning algorithms in predicting NAC response. RESULTS: Of 655 articles identified, 12 studies comprising 1523 patients were included, and four studies were eligible for meta-analysis. The sensitivity and specificity of the studies were 0.62 (95% confidence interval [CI] 0.50–0.72) and 0.82 (95% CI 0.72–0.89), respectively, with a heterogeneity score (I²) of 38.5%. The machine learning algorithms used computed tomography, genetic, and anatomopathologic data as input and exhibited promising potential for predicting NAC response.
- Subjects
NON-muscle invasive bladder cancer; MEDICAL information storage &; retrieval systems; ARTIFICIAL intelligence; TREATMENT effectiveness; META-analysis; SYSTEMATIC reviews; MEDLINE; COMBINED modality therapy; MEDICAL databases; MEDICAL records; ACQUISITION of data; ALGORITHMS; SENSITIVITY &; specificity (Statistics); ERIC (Information retrieval system)
- Publication
Canadian Urological Association Journal, 2024, Vol 18, Issue 9, pE276
- ISSN
1911-6470
- Publication type
Article
- DOI
10.5489/cuaj.8681