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- Title
N-3 PUFA supplementation alleviates anxiety symptoms by manipulating erythrocyte fatty acid levels in depression.
- Authors
Wang, Lu; Liu, Ting; Guo, Jimin; Zhao, Tingyu; Tang, Hui; Wang, Feifei; Dong, Fang; Chen, Jindong; Tang, Mimi
- Abstract
Purpose: Major depressive disorder (MDD) is frequently accompanied by the symptoms of clinical anxiety. Since our previous research has found that n-3 PUFA supplementation alleviates anxiety in MDD, this study was aimed to further explore whether n-3 PUFA supplementation improves anxiety symptoms in depression by directly manipulating fatty acid levels. Methods: A secondary analysis of biomarker data (erythrocyte fatty acid composition) collected as part of the randomized clinical trial which investigated the adjunctive effect of n-3 PUFAs was conducted on 72 venlafaxine-treated outpatients with first-diagnosed, drug-naïve depression. All participants with longitudinal biomarker data were included in the association analysis to determine how n-3 PUFA supplementation influences fatty acid composition and alleviates anxiety symptoms in depression. Results: Decreases of the C20:3n6 were found in all participants at both follow-up time points (χ2 = 96.36, p = 0.000). The n-3 index (χ2 = 10.59, p = 0.001), EPA (χ2 = 24.31, p = 0.000), and C22:5n3/C20:5n3 ratio (χ2 = 10.71, p = 0.001) were increased, while C22:4n6 (χ2 = 7.703, p = 0.006) was decreased in n-3 PUFA group compared to the placebo group. The improvement in anxiety symptoms positively correlates with the extent of reduction of C16:0, C18:0, and total fatty acid levels as well as D5 desaturase activity (p < 0.05). Conclusion: These data suggest that the anxiolytic effect exerted by n-3 PUFAs in first-diagnosed, drug-naïve depression is manipulated by erythrocyte fatty acid levels. Saturated fatty acid levels have an important role in predicting the severity of anxiety symptoms.
- Subjects
ANXIETY prevention; THERAPEUTIC use of omega-3 fatty acids; ERYTHROCYTES; SECONDARY analysis; RESEARCH funding; OMEGA-3 fatty acids; TREATMENT effectiveness; TRANQUILIZING drugs; DESCRIPTIVE statistics; FATTY acids; DIETARY supplements; MENTAL depression; BIOMARKERS; PHARMACODYNAMICS
- Publication
European Journal of Nutrition, 2024, Vol 63, Issue 6, p2271
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-024-03421-y