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- Title
Survival trends in gastric cancer in Brazil: real-life data from a large cancer center.
- Authors
Carvalho Brito, Angelo Borsarelli; Cordeiro Felismino, Tiago; Mendonca Silva, Diego Rodrigues; Curado, Maria Paula; Durant, Lais Corsino; Gomes Taboada, Rodrigo; Graicer Pelosof, Adriane; Landskron Diniz, Alessandro; Fernandez Coimbra, Felipe Jose
- Abstract
Background: Gastric cancer (GC) is the fourth leading cause of cancer deaths globally. There is a paucity of real-life data on GC in Brazil. Our study aimed to evaluate survival trends in gastric adenocarcinoma (GA) in a large cancer center in Brazil during 2000-2017. Methods: Based on our Hospital Cancer Registry Database, all individuals diagnosed with GA between 2000 and 2017, and treated at A.C. Camargo Cancer Center, were retrospectively included. The primary objectives were to describe the patient demographics, clinicopathological characteristics, treatment modalities and survival trends during four separate periods of diagnosis (2000-2004; 2005-2009; 2010-2014 and 2015-2017). χ² test was performed between two specified periods (2000-2004 and 2015-2017) to compare categorical variables. Overall survival (OS) curves were stratified by four separate periods and compared with log-rank tests. Results: This analysis included 1,406 individuals. Across all periods, most patients were men aged 50-69 and presented with Lauren's intestinal subtype. The frequency of stage IV disease significantly decreased between 2000-2004 and 2015-2017 (43.6% to 32.8%, p < 0.001). In contrast, we observed a rise in stage II (9.4% to 24.8%, p < 0.001) in the same comparison. We noticed an increased utilization of a combined approach involving chemotherapy and surgery (12% in 2000-2004 and 36.3% in 2015-2017, p < 0.001). The predicted 5-year OS of patients with GA in 2000-2004 was 27.8%, which increased to 53.9% in 2015-2017 (p < 0.001). Conclusion: Our retrospective cohort showed an upward trend in survival rates during the period. We observed that 5-year OS almost doubled among men and women during 2000-2017.
- Subjects
STOMACH cancer; OVERALL survival; EPIDEMIOLOGY of cancer; LOG-rank test; CANCER hospitals
- Publication
Ecancermedicalscience, 2024, Vol 18, Issue 1676-1753, p1
- ISSN
1754-6605
- Publication type
Article
- DOI
10.3332/ecancer.2024.1706