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- Title
Eco‐Friendly Production of 2D Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene and Cytotoxicity Mitigation Toward Biomedical Applications.
- Authors
Sankar, Siva Nemala; Araujo, Guilherme; Fernandes, João; Cerqueira, Fatima; Alpuim, Pedro; Ribeiro, Ana R.; Lebre, Filipa; Alfaro‐Moreno, Ernesto; Placidi, Ernesto; Marras, Sergio; Capasso, Andrea
- Abstract
2D MXenes find applications in several technology fields. Solution processing techniques can facilitate the integration of these materials within the technological supply chain. Here, a highly concentrated (up to 1.5 g L−1) and stable dispersion of 2D Ti3C2Tx MXene flakes is produced by an environmentally friendly liquid phase exfoliation process (LPE) in dihydrolevoglucosenone (Cyrene). The flakes preserve their elemental composition after 6 months, while those exfoliated in N‐Methyl‐2‐pyrrolidone (NMP), a commonly used solvent, undergo significant oxidation. The cytotoxicity of the MXene flakes in Cyrene and in NMP is investigated by assessing the cellular viability in a human keratinocyte (HaCaT) cell line, which is a relevant model for skin applications. The data show that the MXene flakes in Cyrene induce cytotoxic effects for a dose > 1 µg cm−2, as similarly observed for the MXene flakes in NMP. Efforts are made to overcome this by collecting the MXene flakes and redispersing them in a solution of bovine serum albumin (BSA). MXene in BSA does not affect cellular viability and cell morphology, possibly due to the formation of a protective protein corona around the individual MXene flakes. These findings illustrate an environmentally friendly strategy to produce biocompatible 2D MXene for biomedical applications.
- Subjects
CELL morphology; CYTOTOXINS; SERUM albumin; CELL survival; CELL lines; KERATINOCYTE differentiation
- Publication
Advanced Materials Interfaces, 2024, Vol 11, Issue 24, p1
- ISSN
2196-7350
- Publication type
Article
- DOI
10.1002/admi.202400203