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- Title
Mast cell responses in a mouse model of food allergy are regulated via a ST2/IL‐4 axis.
- Authors
Ranjitkar, Saurav; Krajewski, Dylan; Tedeschi, Caitlin; Perez, Nicole Maldonado; Jordan, Nathan; Gregory, Kelly; Schneider, Sallie S.; Mathias, Clinton B.
- Abstract
This article discusses the role of IL-33, an alarmin cytokine, in regulating mast cell responses during food allergy. The IL-33 receptor, ST2, is expressed on mast cells, and genetic variations in the IL-33/ST2 axis are associated with disease susceptibility. The study used a mouse model of food allergy and found that IL-33 is critical for inducing mast cell responses to food antigens. Mice lacking ST2 showed decreased diarrhea, mast cell accumulation, and mast cell activation compared to wild-type mice. The study also found that IL-4 plays a role in mediating mast cell responses, as treatment with IL-4 reversed the attenuated mast cell activation in ST2-deficient mice. These findings provide insights into the potential interplay between IL-33 and IL-4 in the treatment of allergic diseases.
- Subjects
TH2 cells; INNATE lymphoid cells; ANAPHYLAXIS; FOOD allergy; MAST cells
- Publication
Allergy, 2024, Vol 79, Issue 9, p2561
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.16257