We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dependence of Anticancer Activity of Camptothecins on Maintaining Their Lactone Function.
- Authors
GIOVANELLA, B. C.; HARRIS, N.; MENDOZA, J.; CAO, Z.; LIEHR, J.; STEHLIN, J. S.
- Abstract
A bstract: Camptothecins contain a lactone ring that exists in the closed form below ph 7. Above 7, the open (CPT+) and the closed (CPT) form coexist in a 50-50 ratio in mouse plasma and in a 90-10 ratio in human plasma due to the high affinity of human serum albumin (HSA) for CPT+. CPT+ is much less toxic than CPT and it is excreted much faster. In complete RPMI 1640 culture medium, the equilibrium CPT+-CPT is 50-50. If 4% HSA is added, it moves to 90-10 modeling for the human physiological situation.
- Publication
Annals of the New York Academy of Sciences, 2000, Vol 922, Issue 1, p27
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2000.tb07022.x