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- Title
Identification of molecular target of diallyl trisulfide in leukemic cells.
- Authors
Shun Suda; Kazunari Watanabe; Yuki Tanaka; Kazuhiro Watanabe; Rie Tanaka; Jun Ogihara; Toyohiko Ariga; Tomomi Hosono-Fukao; Takashi Hosono; Taiichiro Seki
- Abstract
The article focuses on a study which examined the modification of thiol group(s) of cellular proteins using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) in order to identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937. Topics covered include the effect of DATS on the growth of human monocytic leukemia U937 cells, and the protein(s) involved in the formation of either intra- or intermolecular disulfide bond.
- Subjects
ORGANOSULFUR compounds; CANCER cells; LEUKEMIA genetics; CELL lines; DIALLYL disulfide; THIOLS; POLYACRYLAMIDE gel electrophoresis; THERAPEUTICS
- Publication
Bioscience, Biotechnology & Biochemistry, 2014, Vol 78, Issue 8, p1415
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2014.921563