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- Title
Determination of α-Lipoic acid on a Pyrolytic Graphite Electrode Modified with Cobalt Phthalocyanine.
- Authors
Ferreira, Ana Paula M.; dos Santos Pereira, Laise N.; da Silva, Iranaldo Santos; Tanaka, Sônia M. C. N.; Tanaka, Auro A.; Angnes, Lúcio
- Abstract
In this work voltammetric techniques were explored for quantification of α-Lipoic acid (ALA) using a pyrolytic graphite electrode modified with cobalt phthalocyanine. Cyclic voltammograms recorded in phosphate buffer solution containing 1×10−3 mol L−1 of ALA presented an oxidation peak located at +0.8 V vs. SCE. The modification of the electrode produced a 100 mV shift of the onset oxidation potential to less positive value and a substantial increase in the ALA oxidation current. Among the voltammetric techniques explored, differential pulse voltammetry showed the best performance for quantifications of the analyte in low concentrations. Limits of detection and quantification of ALA obtained corresponds to 3.4×10−9 mol L−1 and 1.2×10−8 mol L−1, respectively.
- Subjects
LIPOIC acid; GRAPHITE; PHTHALOCYANINES; COBALT; VOLTAMMETRY; OXIDATION
- Publication
Electroanalysis, 2014, Vol 26, Issue 10, p2138
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201400421