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- Title
Cobalt‐Catalyzed Intermolecular [2+2] Cycloaddition between Alkynes and Allenes.
- Authors
Ding, Wei; Yoshikai, Naohiko
- Abstract
An intermolecular [2+2] cycloaddition reaction between an alkyne and an allene is reported. In the presence of a cobalt(I)/diphosphine catalyst, a near equimolar mixture of the alkyne and allene is converted into a 3‐alkylidenecyclobutene derivative in good yield with high regioselectivity. The reaction tolerates a variety of internal alkynes and mono‐ or disubstituted allenes bearing various functional groups. The reaction is proposed to involve regioselective oxidative cyclization of the alkyne and allene to form a 4‐alkylidenecobaltacyclopentene intermediate, with subsequent C−C reductive elimination.
- Subjects
ALKYNES; ALLENE; INTERMOLECULAR interactions; COBALT; RING formation (Chemistry); DIPHOSPHINE
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 8, p2522
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201813283