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- Title
Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate.
- Authors
Yan, Zhengqing; Qin, Hongshuang; Ren, Jinsong; Qu, Xiaogang
- Abstract
Abstract: The effective guidance of mesenchymal stem cell (MSC) differentiation on a substrate by near‐infrared (NIR) light is particularly attractive for tissue engineering and regenerative medicine. However, most of current substrates cannot control multidirectional differentiation of MSCs like natural tissues. Herein, a photocontrolled upconversion‐based substrate was designed and constructed for guiding multidirectional differentiation of MSCs. The substrate enables MSCs to maintain their stem‐cell characteristics due to the anti‐adhesive effect of 4‐(hydroxymethyl)‐3‐nitrobenzoic acid modified poly(ethylene glycol) (P1) attached on the upconversion substrate. Upon NIR irradiation, the P1 is released from the substrate by photocleavage. The detachment of P1 can change cell–matrix interactions dynamically. Moreover, MSCs cultured on the upconversion substrate can be specifically induced to differentiate to adipocytes or osteoblasts by adjusting the NIR laser. Our work provides a new way of using NIR‐based upconversion substrate to modulate the multidirectional differentiation of MSCs.
- Subjects
PHOTON upconversion; STEM cells; TISSUE engineering; POLYETHYLENE glycol; NITROBENZOIC acid
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 35, p11352
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201803939