We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Identification of Tumor Initiating Cells with a Small‐Molecule Fluorescent Probe by Using Vimentin as a Biomarker.
- Authors
Lee, Yong‐An; Kim, Jong‐Jin; Sahu, Srikanta; Park, Sung‐Jin; Chang, Young‐Tae; Kang, Nam‐Young; Lee, Jungyeol; Wang, Zhenxun; Lim, Bing; Lee, Jia Hui Jane; Tam, Wai Leong; Kwon, Haw‐Young; Jang, Se‐Young; Lee, Jun‐Seok
- Abstract
Abstract: Tumor initiating cells (TICs) have been implicated in clinical relapse and metastasis of a variety of epithelial cancers, including lung cancer. While efforts toward the development of specific probes for TIC detection and targeting are ongoing, a universal TIC probe has yet to be developed. We report the first TIC‐specific fluorescent chemical probe, TiY, with identification of the molecular target as vimentin, a marker for epithelial‐to‐mesenchymal transition (EMT). TiY selectively stains TICs over differentiated tumor cells or normal cells, and facilitates the visualization and enrichment of functionally active TICs from patient tumors. At high concentration, TiY also shows anti‐TIC activity with low toxicity to non‐TICs. With the unexplored target vimentin, TiY shows potential as a first universal probe for TIC detection in different cancers.
- Subjects
VIMENTIN; SMALL molecules; FLUORESCENT probes; LIVER metastasis; NON-small-cell lung carcinoma; XENOGRAFTS
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 11, p2901
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201712920