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- Title
Asymmetric Dearomatization of β-Naphthols through a Bifunctional-Thiourea-Catalyzed Michael Reaction.
- Authors
Wang, Shou ‐ Guo; Liu, Xi ‐ Jia; Zhao, Qun ‐ Chao; Zheng, Chao; Wang, Shao ‐ Bo; You, Shu ‐ Li
- Abstract
An intermolecular asymmetric dearomatization reaction of β-naphthols with nitroethylene through a chiral-thiourea-catalyzed Michael reaction is described. Enantioenriched functionalized β-naphthalenones with an all-carbon quaternary stereogenic center could thus be easily constructed from simple naphthol derivatives in good yields and excellent enantioselectivity (up to 79% yield, 98% ee).
- Subjects
AROMATIZATION; NAPHTHOL; BIFUNCTIONAL catalysis; THIOUREA; MICHAEL reaction; ENANTIOSELECTIVE catalysis
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 49, p15142
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201507998