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- Title
Copper(I)-Catalyzed Alkylation of Polyfluoroarenes through Direct C-H Bond Functionalization.
- Authors
Shuai Xu; Guojiao Wu; Fei Ye; Xi Wang; Huan Li; Xia Zhao; Yan Zhang; Jianbo Wang
- Abstract
The copper(I)-catalyzed alkylation of electron-deficient polyfluoroarenes with N-tosylhydrazones and diazo compounds has been developed. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of C(sp2)- C(sp3) bonds with polyfluoroarenes through direct C-H bond functionalization. Mechanistically, copper(I) carbene formation and subsequent migratory insertion are proposed as the key steps in the reaction pathway.
- Subjects
COPPER catalysts; ALKYLATION; AROMATIC fluorine compounds; CARBON-hydrogen bonds; FUNCTIONAL groups
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 15, p4752
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201412450