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- Title
Direct α-Arylation of Ethers through the Combination of Photoredox-Mediated C-H Functionalization and the Minisci Reaction.
- Authors
Jian Jin; MacMillan, David W. C.
- Abstract
The direct α-arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox-mediated C-H functionalization pathway. Transiently generated α-oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron-deficient heteroarenes in a Minisci-type mechanism. This mild, visiblelight- driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst.
- Subjects
ETHER derivatives; ARYLATION; OXIDATION-reduction reaction; CARBON-hydrogen bonds; HYDROGEN atom; RADICAL photosubstitution; HETEROARENES
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 5, p1585
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201410432