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- Title
Exposure of Staphylococcus aureus to silver(I) induces a short term protective response.
- Authors
Smith, Alanna; Rowan, Raymond; McCann, Malachy; Kavanagh, Kevin
- Abstract
The Ag(I) ion has well established anti-bacterial and antifungal properties. Exposure of Staphylococcus aureus to MIC AgNO (3 μg/ml) lead to an increase in the activity of superoxide dismutase, glutathione reductase and catalase at 30 min but activity declined by 60 min. In addition, exposure of cells to this metal ion for 1 h lead to increased expression of a number of proteins such as elongation factors Ts, Tu and G, fructose-bisphosphate aldolase and triosephosphate isomerase but their expression declined following 4 h exposure. ATP binding cassette transporter protein and oligoendopeptidase F showed increased expression at 4 h. While Ag(I) is a potent antimicrobial agent this work demonstrates that S. aureus can mount a short-term protective response to exposure to the metal ion but that this is eventually overcome.
- Subjects
ANTI-infective agents; SILVER; ANTIFUNGAL agents; STAPHYLOCOCCUS; PROTEOMICS; OXIDATIVE stress
- Publication
BioMetals, 2012, Vol 25, Issue 3, p611
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-012-9549-3