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- Title
Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway.
- Authors
Zhenwei Zhang; Lei Miao; Xiaoming Xin; Jianpeng Zhang; Shengsheng Yang; Mingyong Miao; Xiangping Kong; Binghua Jiao
- Abstract
Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly downregulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal–related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
- Publication
Molecular Medicine, 2014, Vol 20, Issue 1, p17
- ISSN
1076-1551
- Publication type
Article
- DOI
10.2119/molmed.2013.00102