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- Title
Parkin variants in North American Parkinson's disease: Cases and controls.
- Authors
Sarah J. Lincoln; Demetrius M. Maraganore; Timothy G. Lesnick; Rebecca Bounds; Mariza de Andrade; James H. Bower; John A. Hardy; Matthew J. Farrer
- Abstract
We report on an evaluation of coding variants within the parkin gene to assess their frequency in a North American clinical series of 313 Parkinson's disease (PD) cases and 192 unrelated controls. We hypothesized that the carrier frequency of parkin coding mutations, exon deletions, or duplications may be greater in PD cases. However, point mutations and exonic deletions/duplications, reported previously as pathogenic in homozygous or compound heterozygous individuals, occurred in both cases and controls with similar frequencies (3.8% in cases, 3.1% in controls). Furthermore, only stratified subanalyses detected any genetic association between the V380L common coding polymorphism and PD. We discuss the implication of parkin mutations for Parkinson's disease from this population perspective. © 2003 Movement Disorder Society
- Subjects
PARKINSON'S disease; GENES; MEDICAL genetics; HETEROZYGOSITY; NEUROLOGICAL disorders
- Publication
Movement Disorders, 2003, Vol 18, Issue 11, p1306
- ISSN
0885-3185
- Publication type
Article
- DOI
10.1002/mds.10601