We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection.
- Authors
Bi, Sheng; Sheng, Jifang; Xu, Kaijin; Huang, Cheng; Zheng, Beiwen; Yao, Xin; Zheng, Xia; Xuan, Tianming; Yang, Qing
- Abstract
Introduction: A woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study. Case report: Tigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Subsequent experiments showed that the isolates of the KPC-2-producing K. pneumoniae ST11 clone caused the infection. Conclusion: Therefore, tigecycline and meropenem combination should be used with caution.
- Subjects
COMBINATION drug therapy; KLEBSIELLA infections; IN vitro studies; MEROPENEM
- Publication
Infection, 2019, Vol 47, Issue 3, p497
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-019-01274-w