We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Validation of functional liver imaging scores (FLIS) derived from gadoxetic acid–enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Child-Pugh score and FLIS.
- Authors
Lee, Ho Jun; Hong, Seung Baek; Lee, Nam Kyung; Kim, Suk; Seo, Hyung Il; Kim, Dong Uk; Han, Sung Yong; Choo, Ki Suk
- Abstract
Objectives: To validate the functional liver imaging score (FLIS) for prediction of hepatic function in gadoxetic acid–enhanced MRI. Methods: We retrospectively identified 134 patients (88 men, 46 women; mean age, 58.8 years) between January 2015 and December 2018 with the following inclusion criteria: patients diagnosed with liver cirrhosis or chronic liver disease (CLD) who underwent gadoxetic acid–enhanced MRI. Three parameters on hepatobiliary phase images were evaluated for FLIS: liver parenchymal enhancement, biliary excretion, and signal intensity of the portal vein. Patients were classified as CLD (n = 11), Child-Pugh (CP) class A (n = 87), CP B (n = 22), or CP C (n = 14). We assessed the correlation between CP score and both FLIS and its components using Spearman rank correlation. Receiver operating characteristic (ROC) curve analysis was performed to demonstrate the cutoff value of FLIS for differentiating between CP classes. The associations between patient characteristics, serum markers, FLIS, and hepatic decompensation were evaluated with Cox proportional hazard models. Results: FLIS and three FLIS parameters showed strong to very strong correlation with CP score (r = −0.60 to 0.82). ROC curve analysis showed that FLIS ≥ 5 was the optimal cutoff for prediction of CP class A or CLD (sensitivity, 83.7%; specificity, 94.4%; area under the curve [AUC], 0.93). FLIS < 5 was independently associated with the development of first hepatic decompensation in patients with CP A (HR, 50.0; 95% confidence interval, 6.2, 400.4). Conclusion: FLIS showed a strong correlation with hepatic function and can stratify the CP class. In addition, FLIS can help prediction for the development of first decompensation. Key Points: • Functional liver imaging scores (FLIS) and its three parameters, derived from hepatobiliary phase image, have strong to very strong correlations with Child-Pugh (CP) scores. • FLIS can stratify patients with chronic liver disease or liver cirrhosis according to CP classification. • Low FLIS is an independent predictor for first hepatic decompensation in patients with CP class A.
- Subjects
CIRRHOSIS of the liver; CHRONICALLY ill; LIVER diseases; PROPORTIONAL hazards models; STATISTICAL correlation; GADOLINIUM
- Publication
European Radiology, 2021, Vol 31, Issue 11, p8606
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-021-07955-1