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- Title
Doubling time of thymic epithelial tumours on CT: correlation with histological subtype.
- Authors
Choe, Jooae; Lee, Sang; Lim, Soyeoun; Choi, Se; Kim, Namkug; Do, Kyung-Hyun; Seo, Joon; Lee, Sang Min; Choi, Se Hoon; Seo, Joon Beom
- Abstract
<bold>Objectives: </bold>We retrospectively evaluated the doubling time (DT) of thymic epithelial tumours (TET) according to the histological subtype on CT.<bold>Methods: </bold>From January 2005 to June 2016, we enrolled 53 patients who had pathologically confirmed TET and at least two CT scans. Tumour size was measured using a two-dimensional method, and the DT was calculated. DTs were compared among histological subtypes, and factors associated with rapid tumour growth (DT <180 days) were assessed.<bold>Results: </bold>In 42 of the 53 patients (79.2%) the tumours showed interval growth (>2 mm) during follow-up. The median DT for all tumours was 400 days (range 48-1,964 days). There were no significant differences in DT in relation to histological subtype (p = 0.177). When TETs were recategorized into three groups, i.e. low-risk thymomas (types A, AB, B1), high-risk thymomas (types B2, B3), and thymic carcinoma, DT was significantly different among the groups (median DT 436, 381 and 189 days, respectively; p = 0.031). Histological subtype (type B3 and thymic carcinoma) was the single independent predictor of rapid tumour growth.<bold>Conclusions: </bold>The majority of TETs grew during follow-up with variable and relatively slow growth rates. Histological features of aggressive behaviour significantly correlated with a decreased DT and rapid growth.<bold>Key Points: </bold>• The majority of thymic epithelial tumours grew during follow-up (79.2%, 42/53). • Doubling times of thymic epithelial tumours were highly variable (median 400 days). • Histological features of aggressive behaviour significantly correlated with a decreased doubling time.
- Subjects
EPITHELIAL tumors; TUMOR growth; COMPUTED tomography; THYMUS cancer; CANCER treatment
- Publication
European Radiology, 2017, Vol 27, Issue 10, p4030
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-4795-y