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- Title
Multiparametric fully-integrated 18-FDG PET/MRI of advanced gastric cancer for prediction of chemotherapy response: a preliminary study.
- Authors
Lee, Dong; Kim, Se; Im, Seock-Ah; Oh, Do-Youn; Kim, Tae-Yong; Han, Joon; Lee, Dong Ho; Kim, Se Hyung; Han, Joon Koo
- Abstract
<bold>Objectives: </bold>To investigate usefulness of multiparametric fully integrated 18-FDG PET/MRI in predicting treatment response after chemotherapy for unresectable advanced gastric cancers (AGCs).<bold>Methods: </bold>Eleven patients with unresectable AGCs underwent multiparametric 18-FDG PET/MRI examinations prior to chemotherapy. Perfusion parameters obtained via dynamic contrast-enhanced MRI, apparent diffusion coefficient values from diffusion-weighted images, and maximum standardized uptake values (SUVmax) from 18-FDG PET were measured. For parameters obtained from 18-FDG PET/MRI data, interobserver agreement was obtained using intraclass correlation coefficients (ICC) and chemotherapy response relationship was evaluated using the Mann-Whitney test and receiver operating characteristic analysis.<bold>Results: </bold>After chemotherapy, six patients were classified into the responder group and five patients into the non-responder group. For all parameters, moderate to nearly perfect agreement was achieved (ICC = 0.452-0.911). K (trans) values (P = 0.018) and initial area under the curves (iAUCs) (P = 0.045) of gastric cancers were significantly higher in responder group than in non-responder group. The area under the curve was 0.917 for K (trans) and 0.867 for iAUC. However, SUVmax values were not significantly different between the two groups.<bold>Conclusion: </bold>Multiparametric approach using fully integrated 18-FDG PET/MRI was shown to be feasible for patients with unresectable gastric cancers. In addition, K (trans) and iAUC values can be used as early predictive markers for chemotherapy response.<bold>Key Points: </bold>• Multiparametric 18-FDG PET/MRI is feasible for patients with unresectable advanced gastric cancer • K (trans) and iAUC were significantly higher in the responder group of patients • K (trans) , iAUC can be utilized as early predictive markers for chemotherapeutic response.
- Subjects
STOMACH cancer; CANCER chemotherapy; STOMACH; POSITRON emission tomography; CONTRAST media; MAGNETIC resonance imaging; PROGNOSIS; ANTINEOPLASTIC agents; DEOXY sugars; RADIOPHARMACEUTICALS; TUMOR classification; STOMACH tumors; RECEIVER operating characteristic curves; PHARMACODYNAMICS; DIAGNOSIS
- Publication
European Radiology, 2016, Vol 26, Issue 8, p2771
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-4105-5