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- Title
A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis.
- Authors
Godfrey EM; Patterson AJ; Priest AN; Davies SE; Joubert I; Krishnan AS; Griffin N; Shaw AS; Alexander GJ; Allison ME; Griffiths WJ; Gimson AE; Lomas DJ; Godfrey, Edmund M; Patterson, Andrew J; Priest, Andrew N; Davies, Susan E; Joubert, Ilse; Krishnan, Anant S; Griffin, Nyree
- Abstract
<bold>Objectives: </bold>Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using (31)P spectroscopy against histological fibrosis staging.<bold>Methods: </bold>The local research ethics committee approved this prospective, blinded study. A total of 77 consecutive patients (55 male, aged 49 ± 11.5 years) with a clinical suspicion of liver fibrosis underwent an MR examination with a liver biopsy later the same day. Patients underwent MRE and (31)P spectroscopy on a 1.5 T whole body system. The liver biopsies were staged using an Ishak score for chronic hepatitis or a modified NAS fibrosis score for fatty liver disease.<bold>Results: </bold>MRE increased with and was positively associated with fibrosis stage (Spearman's rank = 0.622, P < 0.001). PME/PDE was not associated with fibrosis stage (Spearman's rank = -0.041, p = 0.741). Area under receiver operating curves for MRE stiffness values were high (range 0.75-0.97). The diagnostic utility of PME/PDE was no better than chance (range 0.44-0.58).<bold>Conclusions: </bold>MRE-estimated liver stiffness increases with fibrosis stage and is able to dichotomise fibrosis stage groupings. We did not find a relationship between (31)P MR spectroscopy and fibrosis stage.<bold>Key Points: </bold>Magnetic resonance elastography (MRE) and MR spectroscopy can both assess the liver. MRE is superior to ( 31 ) P MR spectroscopy in staging hepatic fibrosis. MRE is able to dichotomise liver fibrosis stage groupings. Gradient-echo MRE may be problematic in genetic haemochromatosis.
- Publication
European Radiology, 2012, Vol 22, Issue 12, p2790
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-012-2527-x