We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan.
- Authors
Kang, Yu-Mei; Lin, Shih-Chieh; Lee, Yi-Yen; Chang, Feng-Chi; Liang, Muh-Lii; Chen, Hsin-Hung; Wong, Tai-Tong; Chen, Yi-Wei
- Abstract
Purpose: A basal ganglia (BG) germinoma is a rare tumor, and the optimal treatment remains unknown. We evaluated the clinical outcomes of treatment of BG germinoma in pediatric patients in Taiwan. Methods: We retrospectively reviewed the medical records of 34 children with BG germinoma who were treated with radiotherapy (RT) at Taipei Veterans General Hospital between 1989 and 2016. The median follow-up time is 8.3 years (1.8–25.2 years). Survival was analyzed using the Kaplan–Meier estimate. Univariate Cox proportional-hazards models were used to identify the potential risk factors. Results: Only four patients (11.8%) experienced recurrence and all successfully underwent salvage therapy. One patient (2.97%) died due to suspected radiotherapy (RT)-related sarcoma in the scalp. The 2-, 3-, and 5-year DFS rates were 91.2%, 88.2%, and 79.4%, respectively; the 2-, 3-, and 5-year OS rates were 97.1%, 94.1%, and 82.4%, respectively. Focal RT showed low DFS in the Kaplan–Meier survival curves (P =.028) compared with non-focal RT (whole ventricle, whole brain, or cranial spinal area). In the univariate Cox proportional-hazards model, there was a significant difference in DFS between focal and non-focal RT (P =.03). There is no difference in DFS and OS between BG germinoma patients and non-BG germinoma patients. Conclusions: We found an excellent DFS and OS in pediatric patients with BG germinoma treated with RT. Whole ventricle irradiation is recommended for good tumor control and low treatment-related toxicity. BG germinoma patients showed similar treatment results as germinoma patients in other common sites.
- Subjects
TAIWAN; GERMINOMA; BASAL ganglia; PEDIATRIC therapy; TREATMENT effectiveness; SALVAGE therapy
- Publication
Child's Nervous System, 2020, Vol 36, Issue 8, p1745
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-020-04543-4