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- Title
Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases.
- Authors
Iwasaki, Shin-ichi; Sudo, Tamotsu; Miwa, Maiko; Ukita, Masayo; Morimoto, Akemi; Tamada, Masaru; Ueno, Sayaka; Wakahashi, Senn; Yamaguchi, Satoshi; Fujiwara, Kiyoshi; Sakuma, Yoshiko; Mikami, Yoshiki; Nishimura, Ryuichiro
- Abstract
Purpose: Endometrial stromal sarcomas (ESSs) are rare tumors and are divided into two groups: low-grade endometrial stromal sarcoma (ESS-LG) and undifferentiated endometrial sarcoma (UES). The purpose of this study was to compare the clinicopathological features and immunophenotypes of ESS-LG and UES. Methods: The authors evaluated 16 patients diagnosed with ESS at the Hyogo Cancer Center, reviewed their files and data, and performed an immunohistochemical study for oncogenic proteins (EGFR, PDGFR-α, and PDGFR-β) and cell cycle regulators (cyclin D1, cyclin E, p16, p21, p27, and p53) to compare ESS-LG and UES using the World Health Organization (WHO) classification. Results: Four cases (25 %) were classified as ESS-LGs and 12 (75 %) as UES. Patients with UES had a significantly worse overall survival than did those with ESS-LG ( p = 0.0445). Although no ESS-LGs showed expression of p16, 10 of 12 (83 %) UESs showed expression of p16. UESs showed a trend toward higher expression of cyclin D1, p21, and p53 compared with ESS-LGs. Conclusions: Our data emphasize the clinical importance of the WHO classification of ESS. It is of utmost importance to establish a proper classification to increase the consistency of data that may be useful for improving clinical and therapeutic management of patients with ESS.
- Subjects
ENDOMETRIAL cancer; IMMUNOPHENOTYPING; COMPARATIVE studies; CELL cycle; IMMUNOHISTOCHEMISTRY; ONCOGENIC proteins; DATA analysis; WORLD Health Organization
- Publication
Archives of Gynecology & Obstetrics, 2013, Vol 288, Issue 2, p385
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-013-2766-3