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- Title
Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma.
- Authors
Gakis, Georgios; Efstathiou, Jason a.; Daneshmand, Siamak; Keegan, Kirk a.; Clayman, Rebecca H.; Hrbacek, Jan; ali-El-Dein, Bedeir; Zaid, Harras B.; Schubert, Tina; Mischinger, Johannes; Todenhöfer, Tilman; Galland, Sigolene; Olugbade Jr., Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S.; Babjuk, Marko; Thalmann, George N.; Stenzl, arnulf
- Abstract
Introduction: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. Methods: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan- Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. Results: Syn-chronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020). Conclusion: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.
- Subjects
BLADDER cancer; URETHRAL cancer; URINARY organ cancer; KAPLAN-Meier estimator; ONCOLOGY
- Publication
Urologia Internationalis, 2016, Vol 97, Issue 2, p134
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000448335