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- Title
Bladder Tumor Heterogeneity: The Impact on Clinical Treatment.
- Authors
Chen, Chao; Qi, Xiang Jie; Cao, Yan Wei; Wang, Yong Hua; Yang, Xue Cheng; Shao, Shi Xiu; Niu, Hai Tao
- Abstract
Bladder cancer relapse and treatment failure in most patients have often been attributed to chemoresistance in tumor cells and metastasis. Emerging evidence indicates that tumor heterogeneity may play an equally important role and extends to virtually all measurable properties of cancer cells. Although the idea of tumor heterogeneity is not new, little attention has been paid to applying it to understand and control bladder cancer progression. With the development of biotechnology, such as Gene sequencing, recent advances in understanding its generation model, original basis, consequent problems, and derived therapies provide great potential for tumor heterogeneity to be considered a new insight in the treatment of bladder cancers. © 2015 S. Karger AG, Basel
- Subjects
BLADDER tumors; DRUG resistance in cancer cells; CANCER chemotherapy; CANCER relapse; BIOTECHNOLOGY; INDIVIDUALIZED medicine; TUMOR treatment
- Publication
Urologia Internationalis, 2015, Vol 95, Issue 1, p1
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000370165