We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of Cimetidine on Absorption of Oral Tetracycline in Mice.
- Authors
Garty, Moshe; Hurwitz, Aryeh
- Abstract
Gastric administration of cimetidine, 5 mg/kg, and magnesium aluminum hydroxide gel (Maalox®), 1 ml/kg, were equally effective in raising the gastric pH of mice from 2.5 to 5.0. The antacid depressed by 75% gastrointestinal absorption of tetracycline given by gastric tube at 25 mg/kg. Antibiotic bioavailability was measured by area under the plasma level-time curve, peak plasma level and urinary elimination. Cimetidine did not affect tetracycline absorption as reflected by any of these three parameters. If confirmed with the solid dosage form in man, the present study suggests that unlike magnesium aluminum hydroxide gel, cimetidine may be used as an effective means of reducing gastric acid in patients who take tetracycline. Copyright © 1980 S. Karger AG, Basel
- Publication
Pharmacology, 1980, Vol 20, Issue 3, p155
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000137359