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- Title
Bovine respiratory syncytial virus infection: immunopathogenic mechanisms.
- Authors
Gershwin, Laurel J.
- Abstract
Bovine respiratory syncytial virus (BRSV) causes severe respiratory disease in young cattle. Much like the human respiratory syncytial virus, BRSV induces immunomodulation in the infected host, favoring a Th2 response. Several groups have demonstrated IgE responses to BRSV proteins during infection and particularly in response to vaccination with formalin-inactivated vaccine in the field and experimentally. Newer vaccine modalities that favor a shift to Th1 cytokine production have provided promising results. Infection with BRSV is a major contributor to the multi-pathogen disease, bovine respiratory disease complex. This review stresses the unique immunomodulatory aspects of BRSV infection, vaccination and its interaction with the host's immune system.
- Subjects
RESPIRATORY syncytial virus; BOVINE pneumonic pasteurellosis; CATTLE diseases; IMMUNOREGULATION; IMMUNOGLOBULIN E; VETERINARY vaccines
- Publication
Animal Health Research Reviews, 2007, Vol 8, Issue 2, p207
- ISSN
1466-2523
- Publication type
Article
- DOI
10.1017/S1466252307001405